The instinct on discovering an integration problem is to modify the circuit. Usually the circuit was fine and the floorplan was not, and the same circuit placed differently would have met specification.
Which means the analog constraints have to enter the floorplan at the point the floorplan is made, not be accommodated afterwards. Where the sensitive blocks sit, where the switching regulator sits, where the supplies and returns run, and how far apart the matched devices are — these are decided once, early, and are expensive to revisit.
Post-layout simulation across corners is then the actual signoff. Schematic-level results are a design aid; they are not a prediction of silicon.