5G NR scales subcarrier spacing across 15, 30, 60 and 120 kHz, and slot duration scales inversely — 1 ms at 15 kHz down to 125 microseconds at 120 kHz. Higher numerology buys lower latency and better phase-noise tolerance at millimetre wave, and it costs proportionally tighter processing deadlines.
That deadline is the design constraint. At 120 kHz spacing the entire receive chain — FFT, channel estimation, equalisation, demodulation, decoding — has to complete inside a fraction of 125 microseconds, because HARQ feedback is due. Miss it and throughput collapses, not gracefully.
In time-division duplex the same clock governs the transmit-to-receive turnaround. Guard periods are set by propagation delay and by how quickly the front end can switch, and getting that wrong shows up as interference to a neighbour rather than as a fault on your own equipment.