Return-path discontinuity. A high-speed signal crossing a plane split has no adjacent return path, so the return current takes a long detour. The result is emissions, crosstalk and an eye that closes for no reason visible in the schematic.
Decoupling by rote. Capacitors placed by convention rather than against a plane impedance target, producing a power delivery network that is fine at DC and resonant somewhere that matters.
Late EMC. Emissions problems discovered at a test house cost a re-spin. Considered at layout, they usually cost nothing.
Optimistic thermal assumptions. A part rated at 85 degrees ambient in a sealed enclosure in direct sun is not operating at 85 degrees ambient.